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What Is 5-HTP?

5-Hydroxytryptophan (5-HTP) is an intermediate in the
natural synthesis of the essential amino acid, tryptophan,
to serotonin. Clinical studies suggest that 5-HTP supports
healthy serotonin levels. In the body, 5-HTP converts to
serotonin with the enzymatic removal of a carboxyl group
(COOH). Serotonin is an important neurotransmitter
involved in the regulation of endocrine and brain activity
responsible for emotion, appetite and sleep/wake cycles.*

Uses For 5-HTP

Emotional Well-Being:

Two open trials and a double blind comparative investigation indicate that 5-HTP provides promising support for emotional well-being. Additional studies indicate similar potential for support.*

Appetite And Weight Management Support:

5-HTP has been shown to help moderate appetite and food cravings in study participants.*

Cranial Vessel Comfort:

In several trials, including one that involved over 100 subjects, 5-HTP has demonstrated the ability to promote healthy cranial vessel comfort and function.*

The Source of 5-HTP

5-HTP is derived from the Griffonia simplicifolia plant.
Hypo-allergenic plant fiber is derived from pine cellulose.

Potential Side Effects Or Precautions for 5-HTP

Not to be taken by pregnant or lactating women.
5-HTP may cause gastrointestinal upset in sensitive individuals.

Potential Drug Interactions of 5-HTP

Do not use concurrently with SSRI medications or MAO

Ingredients and Dosage

Pure Caps 5-HTP 50 mg.

each vegetable capsule contains:

5-hydroxytryptophan (Griffonia simplicifolia) - 50 mg.

Recommended Dosage:

Not to be taken by pregnant or lactating women. Do not use
concurrently with SSRI medications or MAO inhibitors.
16 capsules per day, in divided doses, before meals.

Pure Caps 5-HTP 100 mg.

each vegetable capsule contains

5-hydroxytryptophan (Griffonia simplicifolia) - 100 mg.

Recommended Dosage:

Not to be taken by pregnant or lactating women. Do not use
concurrently with SSRI medications or MAO inhibitors.
13 capsules per day, in divided doses, before meals.


1. Zmilacher K, Battegay R, Gastpar M. L-5-hydroxytryptophan alone and in combination with a peripheral decarboxylase inhibitor in the treatment of depression. Neuropsychobiology. 1988;20(1):28-35.

2. Angst J, Woggon B, Schoepf J. The treatment of depression with L-5-hydroxytryptophan versus imipramine. Results of two open and one doubleblind study. Arch Psychiatr Nervenkr.1977 Oct 11;224(2):175-86.

3. Cangiano C, Laviano A, Del Ben M, Preziosa I, Angelico F, Cascino A, Rossi-Fanelli F. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. Int J Obes Relat Metab Disord1998. Jul;22(7):648-54.

4. Ceci F, Cangiano C, Cairella M, et al. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects. J Neural Transm1989;76(2):10917.

5. Cangiano C, Ceci F, Cascino A, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
Am J Clin Nutr1992;56:8637.

6. Titus F, Davalos A, Alom J, Codina A. 5-hydroxytryptophan versus methysergide in the prophylaxis of migraine. Eur Neurol1986;25:3279.

7. Healthnotes Clinical Essentials. Copyright 2004. Healthnotes, Inc.

*This is a statement of nutritional support. This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

This information is for educational purposes only. Consult your physician for any health problems.

Source: Product Information Sheet from Pure Encapsulations.

Manufacturers continually change product specifications. While we try our best to keep product descriptions up to date, they do not necessarily reflect the latest information available from the manufacturer. We are not responsible for incorrect or outdated product descriptions and/or images.

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