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Acetyl-l-Carnitine

What Is Acetyl-l-Carnitine?

Acetyl-l-carnitine is the acetylated form of l-carnitine. The two compounds share similar energy and metabolism promoting properties. Found naturally in the body, acetyl-l-carnitine supports the availability of acetyl-CoA, an important energy generating metabolite. In addition, it supports proper mitochondrial function and cell membrane stability. The acetyl group from acetyl-l-carnitine is also responsible for the production of acetylcholine, an important neurotransmitter for optimal mental functioning.*

Uses For Acetyl-l-Carnitine

Support For Cognitive Function, Memory, And Emotional Well-Being:

The efficacy of long-term acetyl-l-carnitine supplementation was determined in a double blind, placebo-controlled, randomized trial involving 130 elderly individuals for a one-year period. In this trial, acetyl-l-carnitine demonstrated the ability to slow negative cognitive changes, and supported memory and attention.

In another randomized double blind study, three-month acetyl-l-carnitine supplementation provided statistically significant support for mental function, including memory and attention, compared to placebo.

A multicenter trial of 481 volunteers showed significant memory, behavioral and emotional support with acetyl-l-carnitine supplementation. In an evaluation of 28 elderly individuals using acetyl-l-carnitine or placebo, the supplemented group experienced enhanced emotional well-being.*

Source of Acetyl-l-Carnitine

Acetyl-l-carnitine is derived from acetyl-l-carnitine HCl, a synthetically derived amino acid.

Potential Side Effects Or Precautions When Using Acetyl-l-Carnitine

If pregnant or lactating, consult your physician before taking this product.

Gastrointestinal upset and skin rash have been reported in sensitive individuals.

Potential Drug Interactions of Acetyl-l-Carnitine

At this time, there are no known adverse reactions when taken in conjunction with medications.

Ingredients

Acetyl-l-Carnitine 250 mg.

Each vegetable capsule contains

acetyl-l-carnitine HCl - 250 mg.

vitamin C (as ascorbyl palmitate) - 4 mg.

(hypo-allergenic plant fiber added to complete capsule volume requirement)

Recommended Dosage for Acetyl-l-Carnitine 250 mg

2–4 capsules per day, in divided doses, between meals.

Acetyl-l-Carnitine 500 mg.

each vegetable capsule contains

acetyl-l-carnitine HCl - 500 mg.

vitamin C (as ascorbyl palmitate) - 8 mg.

(hypo-allergenic plant fiber added to complete capsule volume requirement)

Recommended Dosage for Acetyl-l-Carnitine 500 mg

1–2 capsules per day, in divided doses, between meals.

References

1. Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-l-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer’s disease. Int Clin Psychopharmacol2003 Mar;18(2):61-71.

2. Thal LJ, Carta A, Clarke WR, et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer’s disease. Neurology1996;47:705–11.

3. Pettegrew JW, Klunk WE, Panchalingam K, et al. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer’s disease. Neurobiol Aging 1995;16:1-4.

4. Cucinotta D, Passeri M, Ventura S, et al. Multicenter clinical placebocontrolled study with acetyl-L-carnitine (LAC) in the treatment of mildly demented elderly patients. Drug Development Res1988;14:213-6.

5. Garzya G et al. Evaluation of the effects of L-acetylcarnitine on senile patients suffering from depression. Drugs Exp Clin Res.1990;16(2):101-6.

6. Salvioli G, Neri M. L-acetylcarnitine treatment of mental decline in the elderly. Drugs Exp Clin Res.1994;20(4):169-76.

7. Healthnotes Clinical Essentials. Copyright 2004. Healthnotes, Inc.

*This is a statement of nutritional support. This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

This information is for educational purposes only. Consult your physician for any health problems.

Source: Product Information Sheet from Pure Encapsulations

Manufacturers continually change product specifications. While we try our best to keep product descriptions up to date, they do not necessarily reflect the latest information available from the manufacturer. We are not responsible for incorrect or outdated product descriptions and/or images.

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