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B12 Folic™

What Is B12 Folic™?

B12 Folic™ is a combination of two water-soluble B vitamins, folic acid and vitamin B12. These two vitamins are interrelated in function. They convert carbohydrates into energy and are vital in the metabolism of fats and protein. They play an important role in the maintenance of muscle tone in the GI tract, the functioning of the nervous system, and the integrity of skin, hair, and the liver. Folic acid is essential for normal fetal neural development. The B12 in this formula is provided as methylcobalamin, the most bioavailable form of this vitamin, as it does not require intrinsic factor for absorption.*†

Uses For B12 Folic™

Healthy Fetal Neural Development:

Folic acid is an integral factor involved in the formation of nucleic acids and the production of healthy DNA and chromosomes. In particular, this B vitamin is critical for the proper neural and cellular development of the fetal central nervous system. Folic acid promotes healthy cellular differentiation during the formation of the brain and spinal cord, helping to prevent neural tube defects. Additionally, folic acid is important for the growth and reproduction of red and white blood cells.*†  

Nervous System Health:

In recent studies, methylcobalamin has demonstrated an enhanced ability to support neurological function. Vitamin B12 promotes protein synthesis for maintaining healthy nerve cells and myelin. Methylcobalamin may also help to moderate levels of glutamate in the brain, encouraging healthy brain cell activity, as well as memory, mood, and cognitive function. In general, vitamin B12 works with folate to promote DNA and red blood cell health.*

Source for B12 Folic™

Folic acid is synthetically produced. Methylcobalamin is produced from corn dextrose fermentation. Hypo-allergenic plant fiber is derived from pine cellulose. Vitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and palm oil.

Potential Side Effects Or Precautions - B12 Folic™

At this time, there are no known side effects or precautions. If pregnant or lactating, consult your physician before taking this product.

Potential Drug Interactions - B12 Folic™

Folic acid may adversely interact with chemotherapeutic drugs.

Ingredients and Dosage

each B12 Folic™ vegetable capsule contains

methylcobalamin (B12) - 800 mcg.
folic acid - 800 mcg.**
vitamin C (as ascorbyl palmitate) - 2 mg.

(hypo-allergenic plant fiber added to complete capsule volume requirement)

**Provides the recommended dose for pregnant or lactating women.

Recommended Dosage

1–2 capsules per day, in divided doses, with meals.


1. Quinlivan EP, McPartlin J, McNulty H, Ward M, Strain JJ, Weir DG, Scott JM. Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease. Lancet2002 Jan 19;359(9302):227-8.

2. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet1991 Jul 20;338(8760):131-137.

3. Bower C, Stanley FJ. Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia. Med J Aust 1989 Jun 5;150(11):613-619.

4. Morrison HI, Schaubel D, Desmeules M, Wigle DT. Serum folate and risk of fatal coronary heart disease. JAMA1996 Jun 26;275(24):1893-1896.

5. Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology1987;44(3):169-73.

6. Weinberg JB, Shugars DC, Sherman PA, Sauls DL, Fyfe JA. Cobalamin inhibition of HIV-1 integrase and integration of HIV-1 DNA into cellular DNA. Biochem Biophys Res Commun1998 May 19;246(2):393-7.

7. Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol1993 Sep 7;241(1):1-6.

8. Waikakul W, Waikakul S. Methylcobalamin as an adjuvant medication in conservative treatment of lumbar spinal stenosis. J Med Assoc Thai2000 Aug;83(8):825-3.

9. Mayer G, Kroger M, Meier-Ewert K. Effects of vitamin B12 on performance and circadian rhythm in normal subjects. Neuropsychopharmacology 1996 Nov;15(5):456-64.

10. Healthnotes Clinical Essentials. Copyright 2004. Healthnotes, Inc.

*This is a statement of nutritional support. This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

†Women who consume healthful diets with adequate folate may reduce their risk of having a child with birth defects of the brain or spinal cord. Folate intake should not exceed 250% of the DV (1,000 mcg).

This information is for educational purposes only. Consult your physician for any health problems.

Source: Product Information Sheet from Pure Encapsulations

Manufacturers continually change product specifications. While we try our best to keep product descriptions up to date, they do not necessarily reflect the latest information available from the manufacturer. We are not responsible for incorrect or outdated product descriptions and/or images.

See Also:

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