What Is B12 Folic™?
B12 Folic™ is a combination of two water-soluble
B vitamins, folic acid and vitamin B12. These two vitamins
are interrelated in function. They convert carbohydrates
into energy and are vital in the metabolism of fats and
protein. They play an important role in the maintenance
of muscle tone in the GI tract, the functioning of the
nervous system, and the integrity of skin, hair, and the
liver. Folic acid is essential for normal fetal neural
development. The B12 in this formula is provided as
methylcobalamin, the most bioavailable form of this
vitamin, as it does not require intrinsic factor for
Uses For B12 Folic™
Healthy Fetal Neural Development:
Folic acid is an
integral factor involved in the formation of nucleic acids
and the production of healthy DNA and chromosomes. In
particular, this B vitamin is critical for the proper neural
and cellular development of the fetal central nervous
system. Folic acid promotes healthy cellular
differentiation during the formation of the brain and
spinal cord, helping to prevent neural tube defects.
Additionally, folic acid is important for the growth and
reproduction of red and white blood cells.*†
Nervous System Health:
In recent studies, methylcobalamin
has demonstrated an enhanced ability to support
neurological function. Vitamin B12 promotes protein
synthesis for maintaining healthy nerve cells and myelin.
Methylcobalamin may also help to moderate levels of
glutamate in the brain, encouraging healthy brain cell
activity, as well as memory, mood, and cognitive function.
In general, vitamin B12 works with folate to promote DNA
and red blood cell health.*
Source for B12 Folic™
Folic acid is synthetically produced. Methylcobalamin
is produced from corn dextrose fermentation.
Hypo-allergenic plant fiber is derived from pine cellulose.
Vitamin C (ascorbyl palmitate) is derived from corn
dextrose fermentation and palm oil.
Potential Side Effects Or Precautions - B12 Folic™
At this time, there are no known side effects or precautions.
If pregnant or lactating, consult your physician before taking
Potential Drug Interactions - B12 Folic™
Folic acid may adversely interact with chemotherapeutic
Ingredients and Dosage
each B12 Folic™ vegetable capsule contains
methylcobalamin (B12) - 800 mcg.
folic acid - 800 mcg.**
vitamin C (as ascorbyl palmitate) - 2 mg.
(hypo-allergenic plant fiber added to complete capsule volume requirement)
**Provides the recommended dose for pregnant or lactating women.
1–2 capsules per day, in divided doses, with meals.
1. Quinlivan EP, McPartlin J, McNulty H, Ward M, Strain JJ, Weir DG, Scott
JM. Importance of both folic acid and vitamin B12 in reduction of risk of
vascular disease. Lancet2002 Jan 19;359(9302):227-8.
2. MRC Vitamin Study Research Group. Prevention of neural tube defects:
results of the Medical Research Council Vitamin Study. Lancet1991 Jul
3. Bower C, Stanley FJ. Dietary folate as a risk factor for neural-tube
defects: evidence from a case-control study in Western Australia. Med J
Aust 1989 Jun 5;150(11):613-619.
4. Morrison HI, Schaubel D, Desmeules M, Wigle DT. Serum folate and risk
of fatal coronary heart disease. JAMA1996 Jun 26;275(24):1893-1896.
5. Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental
study of antitumor effect of methyl-B12. Oncology1987;44(3):169-73.
6. Weinberg JB, Shugars DC, Sherman PA, Sauls DL, Fyfe JA. Cobalamin
inhibition of HIV-1 integrase and integration of HIV-1 DNA into cellular DNA.
Biochem Biophys Res Commun1998 May 19;246(2):393-7.
7. Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12
analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical
neurons. Eur J Pharmacol1993 Sep 7;241(1):1-6.
8. Waikakul W, Waikakul S. Methylcobalamin as an adjuvant medication in
conservative treatment of lumbar spinal stenosis. J Med Assoc Thai2000
9. Mayer G, Kroger M, Meier-Ewert K. Effects of vitamin B12 on performance
and circadian rhythm in normal subjects. Neuropsychopharmacology
10. Healthnotes Clinical Essentials. Copyright 2004. Healthnotes, Inc.
*This is a statement of nutritional support. This statement has not been
evaluated by the Food & Drug Administration. This product is not intended to
diagnose, treat, cure or prevent any disease.
†Women who consume healthful diets with adequate folate may reduce their risk
of having a child with birth defects of the brain or spinal cord. Folate intake
should not exceed 250% of the
DV (1,000 mcg).
This information is for educational purposes only. Consult your physician for
any health problems.
Source: Product Information Sheet from Pure Encapsulations
Manufacturers continually change product
specifications. While we try our best to keep product descriptions up to date,
they do not necessarily reflect the latest information available from the
manufacturer. We are not responsible for incorrect or outdated product
descriptions and/or images.
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