What Is B-Complex Plus™?
B-Complex Plus™ is an exceptional combination of
B vitamins, including vitamins B1, B2, B3, B5, B6, B12, biotin,
and folic acid, all of which are provided in their optimal
bioavailable and functional forms.*
Features of B-Complex Plus™ Include
• Vitamin B6 (pyridoxine HCl and pyridoxal 5’ phosphate),
supporting amino acid metabolism, nervous system
health, and neurotransmitter (i.e. GABA and serotonin)
synthesis, which studies have reported may help
promote menstrual comfort. Furthermore, pyridoxine
supports healthy red blood cells by participating in
hemoglobin synthesis and some studies indicate it
supports wrist nerve comfort.*
• Vitamin B1 (thiamine HCl), processing carbohydrates,
fat, and protein via its coenzyme form of thiamine
pyrophosphate (TPP). Vitamin B1 is required to form
adenosine triphosphate (ATP), the key source of energy
for the body. Thiamine also promotes neural health.*
• Vitamin B2 (riboflavin and riboflavin 5’ phosphate),
metabolizing nutrients and participating in electron
transport to form ATP. Riboflavin is an integral part of
fatty acid catabolism or β-oxidation and helps convert
folic acid and vitamins B6 to their active states.*
• Vitamin B3 (niacinamide and inositol hexaniacinate),
supporting cardiovascular health by mediating healthy
lipid and carbohydrate metabolism.*
• Vitamin B5 (calcium pantothenate), supporting
cardiovascular health. Pantothenic acid is vital in the
healthy production, transportation, and breakdown of
lipids. Furthermore, this B vitamin promotes the
production of the neurotransmitter acetylcholine.*
• Vitamin B12 (methylcobalamin), supporting healthy
nerve cell activity and DNA replication. Vitamin B12 is
a vital component of the methionine synthase
pathway, which along with folic acid and vitamin B6
supports healthy homocysteine metabolism and
S-adenosylmethionine (SAMe) production.*
• Folic acid, promoting the production of healthy DNA
and chromosomes. In particular, this B vitamin is critical
for the proper neural and cellular development of the
fetal central nervous system, helping to prevent neural
tube defects. In conjunction with vitamins B12 and B6,
folic acid helps to support healthy homocysteine
metabolism. Additionally, this B vitamin is important for
the growth and reproduction of red and white blood
• Biotin, acting as a coenzyme for the metabolism of fat,
carbohydrates and protein.*
Uses For B-Complex Plus™
These B vitamins play important roles in nearly all of the
physiological systems in the body.
Some of the key
supportive roles include:
- the maintenance of muscle tone
in the GI tract,
- the functioning of the nervous system, and
- the integrity of skin, hair, and the liver.
compounds are essential for healthy fetal neural
development, hemoglobin formation, nerve impulse
transmissions, mood, hormone synthesis, and energy
Source for B-Complex Plus™
Pure Encapsulations B-Complex Plus™ formula contains:
Vitamin B1 (thiamine HCl):
Vitamin B2 (riboflavin):
corn dextrose fermentation Niacinamide and Inositol hexaniacinate:
Vitamin B5 (calcium pantothenate):
Vitamin B6 (pyridoxal HCl):
Vitamin B12 (methylcobalamin):
corn dextrose fermentation
Vitamin C (ascorbyl palmitate) is derived from corn dextrose
fermentation and palm oil.
Potential Side Effects Or Precautions -
At this time, there are no known side effects or precautions.
If pregnant or lactating, consult your physician before taking
Potential Drug Interactions - B-Complex Plus™
Folic acid may adversely interact with chemotheraputic
Ingredients and Dosage
each B-Complex Plus™ vegetable capsule contains
thiamine HCl (B1) - 100 mg.
riboflavin (B2) - 5 mg.
riboflavin 5' phosphate (activated B2)- 10 mg.
niacinamide - 100 mg.
inositol hexaniacinate (no-flush niacin) - 10 mg.
pyridoxine HCl (B6) - 10 mg.
pyridoxal 5' phosphate (activated B6) - 10 mg.
pantothenic acid (calcium pantothenate) (B5) - 100 mg.
methylcobalamin (B12) - 400 mcg.
folic acid - 400 mcg.**
biotin - 400 mcg.
vitamin C (as ascorbyl palmitate) - 16 mg.
**2 capsules provide the recommended dose for pregnant or
1–2 capsules per day, in divided doses, with meals.
1. Fujii A, Matsumoto H, Yamamoto H. Effect of vitamin B complex on
and neurite outgrowth. Gen Pharmacol1996 Sep;27(6):995-1000.
2. Kienecker EW, Becker KW, Dick P. Modification of degenerative and
regenerative processes in peripheral nerves by treatment with B vitamins.
Klin Wochenschr1990 Jan 19;68(2):146-8.
3. Bell IR, Edman JS, Morrow FD, Marby DW, Mirages S, Perrone G, Kayne
HL, Cole JO. B complex vitamin patterns in geriatric and young adult inpatients
with major depression. J Am Geriatr Soc1991 Mar;39(3):252-7.
4. Hasegawa K, Mikuni N, Sakai Y. Effects of a vitamin B complex on
recovery after nerve injury. Nippon Yakurigaku Zasshi 1978
5. Selhub J; Jacques PF; Wilson PW; Rush D; Rosenberg IH; Vitamin status
and intake as primary determinants of homocysteinemia in an elderly population.
JAMA1993 Dec 8;270(22):2693-8.
6. Healthnotes Clinical Essentials. Copyright 2004. Healthnotes, Inc.
*This is a statement of nutritional support. This statement has not been
evaluated by the Food & Drug Administration. This product is not intended to
diagnose, treat, cure or prevent any disease.
†Women who consume healthful diets with adequate folate may reduce their risk
of having a child with birth defects of the brain or spinal cord. Folate intake
should not exceed 250% of the
DV (1,000 mcg).
This information is for educational purposes only. Consult your physician for
any health problems.
Source: Product Information Sheet from Pure Encapsulations
Manufacturers continually change product
specifications. While we try our best to keep product descriptions up to date,
they do not necessarily reflect the latest information available from the
manufacturer. We are not responsible for incorrect or outdated product
descriptions and/or images.
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